New Product

KappaRest

Servings per bottle:  180 capsules

Contents per capsule – a proprietary blend of the following:

Curcumin, Piperine, Lipoic Acid, Green Tea Extract, Rosemary Extract, Grape Seed Extract, Propolis, Resveratrol, Phytolens.

Curcumin from Curcuma longa (“Turmeric”): Turmeric is an ancient spice that has been used for thousands of years to add flavour and colour to food. Although in vitro tests and animal studies have suggested that the active components related to curcumin may have potential as powerful agents against human diseases, most researchers and reporters have failed to realise that - in humans - curcumin is very poorly absorbed. Even when curcumin powder is administered in doses as high as 2,000 mg, there is no appreciable increase in serum levels in humans. However, when curcumin is co-administered with piperine, which increases intestinal absorption and reduces enterohepatic detoxification, serum levels of curcumin increase by 2,000% in humans.[1]

Piperine is derived from Piper nigrum, also commonly known as black pepper, a spice found in nearly every kitchen in the world. Piperine enhances absorption and reduces clearance of some drugs such as theophylline (detoxified by CYP3A4 and CYP1A2) and propranolol (detoxified by CYP2D6); this combination of effects (e.g., enhanced absorption and reduced clearance) may require dosage modification for numerous drugs. No adverse reactions have been reported with doses of piperine up to 15 milligrams per day.[2] Pregnant women and nursing mothers should generally avoid piperine supplementation.

Lipoic acid: As a fat-soluble and water-soluble antioxidant with clear biologic activity, it is not surprising that lipoic acid is also noted to inhibit NF-kappaB activity in a dose-dependent manner.[3]

Green tea extract: Epigallocatechin gallate from green tea is an effective inhibitor of IKK activity. Thus, green tea extract inhibits activation of NF-kappaB. This may explain, at least in part, some of the reported benefits of green tea.[4]

Rosemary: Carnosol in rosemary inhibits NF-kappaB activation.[5]

Grape seed extract (GSE): GSE is a potent antioxidant that has been shown to inhibit NF-kappaB.[6]

Propolis (a source of caffeic acid phenethyl ester): Caffeic acid phenethyl ester (CAPE) is an anti-inflammatory component of propolis (honeybee resin) that is a specific inhibitor of NF-kappaB.[7] As with all bee products, allergy to propolis has been reported and may be more common in patients with a history of allergy to honey or other bee products. 

Resveratrol: Resveratrol inhibits NF-kappaB.[8] In fact, according to recent in vitro research, resveratrol and quercetin inhibit NF-kappaB more powerfully than the glucocorticosteroid, dexamethasone.[9] Further support for benefit from resveratrol comes from research showing that resveratrol pretreatment reduces elaboration of COX-2 following administration of the proinflammatory agent, phorbol ester.[10] This effect is almost certainly a reflection of the ability of resveratrol to inhibit NF-kappaB and thereby reduce transcription of proinflammatory genes. 

Phytolens (a patented extract from legumes): Phytolens is a patented polyphenolic extract from lentils. Published experimental research has documented the in vivo antioxidant activity of Phytolens against superoxide other reactive oxygen species.[11]

These statements have not been evaluated by the US Food and Drug Administration. This product is not claimed to diagnose, treat, cure, or prevent any disease. 

Recommended dose

Four capsules 1-3 times per day or as directed by a healthcare provider.

References 

[1] Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6

[2] Piperine. Accessed at http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pip_0322.shtml on April 7, 2005.

[3] Lee HA, Hughes DA.Alpha-lipoic acid modulates NF-kappaB activity in human monocytic cells by direct interaction with DNA. Exp Gerontol. 2002 Jan-Mar;37(2-3):401-10

[4] Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, Varilek GW. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol. 2001 Sep;60(3):528-33

[5] Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis. 2002 Jun;23(6):983-91

[6] Dhanalakshmi S, Agarwal R, Agarwal C. Inhibition of NF-kappaB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int J Oncol. 2003 Sep;23(3):721-7

[7] Fitzpatrick LR, Wang J, Le T. Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappaB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J Pharmacol Exp Ther. 2001 Dec;299(3):915-20

[8] Manna SK, Mukhopadhyay A, Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol. 2000 Jun 15;164(12):6509-19

[9] Donnelly LE, Newton R, Kennedy GE, Fenwick PS, Leung RH, Ito K, Russell RE, Barnes PJ. Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004 Jun 4 [Epub ahead of print]

[10] Subbaramaiah K, Chung WJ, Michaluart P, Telang N, Tanabe T, Inoue H, Jang M, Pezzuto JM, Dannenberg AJ. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem. 1998 Aug 21;273(34):21875-82

[11] Sandoval M, Ronzio RA, Muanza DN, Clark DA, Miller MJ. Peroxynitrite-induced apoptosis in epithelial (T84) and macrophage (RAW 264.7) cell lines: effect of legume-derived polyphenols (phytolens). Nitric Oxide. 1997;1(6):476-83