N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review
For people with obsessive compulsive disorders the condition can be extremely exhausting. For practitioners and clinicians the condition is very frustrating to manage and to bring relief safely and reproducibly. The use of the nutrient N-Acetyl Cysteine as an adjunctive intervention has been explored in a small number of clinical trials, this review paper takes a systematic approach and brings together the evidence to help determine if this single intervention has any clinical value. Read the rest of this entry »
Across the world there are chronic diseases affecting the lives of many, most of which are preventable or modifiable by appropriate lifestyle changes. Yet currently politicians are unwilling to legislate change, to force behaviours that in turn diminish the costs to the individual and to society. Read the rest of this entry »
The idea that bacteria in the gut may have many twists in their skill set to enhance human health has been around for a while. That they may have the capability of inducing a cytoprotective enzyme called Nrf2 in local tissues, which in turn promotes the production of glutathione, detoxification and numerous other health supportive elements has until recently been less well understood.
Nrf2 activation upregulates a regulon of genes including those involved in xenobiotic and reactive oxygen species (ROS) detoxification, as well as pro-restitutive function. This pathway has attracted considerable attention because small molecule inducers of Nrf2 have cytoprotective effects against oxidant and electrophilic environmental stressors., Read the rest of this entry »
It is recognised that in large, the drive for what is being called ‘precision medicine’ (a medical model that proposes the customization of healthcare, with medical decisions, practices, and/or products being tailored to the individual patient) is the lamentable failure of medications to meet the needs of the majority of people who take them. What I mean by this, is that many of the best selling drugs in the world only have a rate of benefit for the people taking them of between 1 in 3 to 1 in 24 – and it may be larger. Statins for example, regularly touted as a solution to raised cholesterol – and as a result sciences answer to an increasingly disputed marker of cardiovascular risk (Just lowering cholesterol with drugs without sorting out the dietary and lifestyle factors that actually cause heart disease is nonsensical), are a highly questionable treatment when viewing the numbers needed to be treated to see a benefit. Read the rest of this entry »
A Possible Link Between Early Probiotic Intervention And The Risk Of Neuropsychiatric Disorders Later In Childhood: A Randomized Trial.
For some time now there has been a growing body of supportive evidence that the relationship between the bacteria in our digestive tract and our central nervous system may not be as tenuous as some may like to think. In a recent study published in Pediatric Research a retrospective review of data in a small but informative group of children, indicates there may be a positive relationship between the use of a well studied probiotic and reduced risk of developing neuropsychiatric illness. Read the rest of this entry »
All Fish Stocks and Fish Oil Products Certified Sustainable
Nordic Naturals is pleased to be recognised with certification from Friend of the Sea (FOS), the international reference standard for producers of omega-3 fish oil. Nordic Naturals sources all of its fish from waters that are certified sustainable by FOS, and all omega-3 products are now FOS certified as well, a reflection of the company’s long-standing commitment to sustainability. Read the rest of this entry »
The growing knowledge in research communities concerning the symbiotic relationship we have with our bacterial organism population is increasingly reflecting that which we have been discussing for many years – namely the use of antibiotics (and many of our current lifestyle habits) is not a benign event in terms of microbiome outcomes. It seems that even short pulses of widely used antibiotics (amoxicillin and tylosin in this paper) can lead to long-term development changes in mouse pups, including increased body mass and bone growth and changes to the gut microbiota, according to a study published in Nature Communications. Read the rest of this entry »
A research paper published in the United European Gastroenterology Journal showed that if you are experiencing a period of remission with Cohn’s disease that Vitamin D confers additional benefit in restoring/maintaining appropriate gut permeability.
In this small study – some 27 people were involved, all of whom were determined to be in remission at the time of the oral supplementation with either 2000 iu of vitamin D or a placebo for 90 days. They found, that patients treated with the supplementation were more likely to maintain their intestinal permeability, whereas this deteriorated in the placebo group. Increased intestinal permeability is considered a measure of gut leakiness, which is shown to predict and precede clinical relapse in CD. In addition, patients with the highest blood levels of vitamin D had signs of reduced inflammation (measured by C-reactive protein and antimicrobial peptides), and these patients also reported better quality of life. Read the rest of this entry »
As part of the ongoing improvements to Nutri-Link’s service, we have updated our terms and conditions to ensure we are fully compliant. These can be a very dull read, but just in case you feel the urge to do so the full terms are available on line by clicking here
There is now considerable scientific evidence that a diet rich in fruits and vegetables can improve human health and protect against chronic diseases. However, it is not clear whether different fruits and vegetables have distinct beneficial effects. A paper in Nutrients published in May 2015 helps to tease apart some of the key mechanisms involved related to the consumption of apples. Read the rest of this entry »